188 papers
Developmental biology explores the incredible journey of how a single cell transforms into a complex, living organism. This field investigates the molecular switches and cellular conversations that guide growth, tissue formation, and the emergence of unique body structures, helping us understand both the origins of life and the roots of developmental disorders.
At Gist.Science, we ensure you never miss a breakthrough by processing every new preprint in this category from bioRxiv. Our team provides both plain-language explanations and detailed technical summaries for each paper, making cutting-edge research accessible to everyone regardless of their scientific background.
Below are the latest studies in developmental biology, offering fresh insights into how life takes shape.
This study demonstrates that the petal identity gene PhDEF exerts distinct regulatory actions and binds different target genes in the petal epidermis versus the mesophyll, revealing that cell layer identity significantly influences the function of floral homeotic genes.
This study demonstrates that uterine stromal ERBB3 signaling is essential for preimplantation glandular branching and embryo implantation by regulating the secretion of IGF1, which acts on epithelial IGF1R to establish a functional stromal environment.
By integrating lineage tracing with single-cell multi-omics, this study reveals that heritable chromatin accessibility states in pluripotent human embryonic stem cells, rather than extrinsic signals alone, drive clonal memory that biases fate decisions and generates heterogeneity during directed endoderm differentiation.
This study reveals that in *Drosophila*, the Nup93-2 paralog, distinct from Nup93-1 in its subnuclear localization, specifically maintains Polycomb-mediated repression of JAK/STAT signaling genes to prevent tumor-like overgrowth, highlighting a unique non-structural role for Nup93-2 in gene silencing.
This study demonstrates that in axolotls, the size of a tail injury dynamically regulates both local and systemic glucose allocation to support tissue regeneration, with larger injuries triggering higher glucose uptake and faster regenerative outgrowth.
This paper has been withdrawn from bioRxiv because a previous version was published without the full consent of all authors, and the authors explicitly request that the work not be cited.
This study demonstrates that transplanting endometrial organoids into an ablated adult uterus restores fertility and reveals that luminal epithelial cells possess the intrinsic plasticity to convert into functional glandular cells during regeneration.
This study demonstrates that the apical extracellular matrix (aECM) mechanically stabilizes and regulates the folding and subsequent unfolding of the *Drosophila* wing disc during development, with its proper formation and removal being essential for correct adult wing morphology.
This study demonstrates that Connexin-43-mediated intercellular communication is essential for regulating Neuromesodermal progenitor states and ensuring the robustness of the segmentation clock during vertebrate axis elongation.
This study introduces the Transgenerational Reset Operator (TRO), an entropy-based computational framework that identifies the morula stage as the developmental nadir of age-associated methylation entropy, revealing that resetting these epigenetic signatures requires coordinated, structured correction rather than independent demethylation.